Pharmacokinetic and biodistribution

Pharmacokinetic and biodistribution studies are essential for understanding how a drug behaves in the body after administration. Pharmacokinetics focuses on the study of absorption, distribution, metabolism, and excretion of a drug, providing key information about the drug’s concentration in various tissues and bodily fluids over time. In contrast, biodistribution examines how a drug is distributed throughout the body and which organs or tissues it accumulates in, which is crucial for assessing its efficacy and safety.

These studies are conducted using cellular and animal models to simulate how the drug disperses and metabolizes in a living organism. Research in pharmacokinetics and biodistribution allows for optimizing drug formulations, adjusting doses, and predicting potential adverse effects. In recent decades, advancements in analytical techniques and the development of experimental models have deepened our understanding of these processes, facilitating the design of more effective and safer therapies.